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Close-up on slices of beef brisket.
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4.97 from 27 votes

Slow-Roasted Beef Brisket

This easy slow-roasted beef brisket in the oven includes a homemade sauce and results in juicy, tender strips of melt-in-your-mouth beef.
Prep Time15 minutes
Cook Time5 hours
Total Time5 hours 15 minutes
Course: Main Course
Keyword: beef brisket in oven, oven brisket, slow roasted brisket
Servings: 10

Ingredients

Beef Brisket

  • 1 fresh beef brisket (4 to 5 pounds)
  • 2 tbsp Worcestershire sauce
  • 2 tbsp soy sauce
  • 1 tbsp onion salt
  • 1 tbsp liquid smoke
  • 2 tsps salt
  • 2 tsps pepper
  • dash hot pepper sauce

Sauce (optional)

  • 1/2 cup ketchup
  • 3 tbsps brown sugar
  • 1 tbsp lemon juice
  • 1 tbsp soy sauce
  • 1 tsp ground mustard
  • 2-3 drops hot pepper sauce
  • dash ground nutmeg

Instructions

  • Place brisket, fat side down, in a 13x9-inch baking dish. In a small bowl, mix the Worcestershire sauce, soy sauce, onion salt, liquid smoke, salt, pepper, and hot pepper sauce and pour it over the brisket. Turn the brisket fat side up and refrigerate, covered, overnight.
    1 fresh beef brisket (4 to 5 pounds), 2 tbsp Worcestershire sauce, 2 tbsp soy sauce, 1 tbsp liquid smoke, 2 tsps salt, 2 tsps pepper, dash hot pepper sauce
  • Remove the brisket from the refrigerator. Preheat oven to 300°. Bake fat side up, covered for 4 hours.
  • Optional: In a small bowl, combine the sauce ingredients and spread it over the brisket. Bake uncovered for 15 to 30 minutes longer or until tender.
    1/2 cup ketchup, 3 tbsps brown sugar, 1 tbsp lemon juice, 1 tbsp soy sauce, 1 tsp ground mustard, 2-3 drops hot pepper sauce, dash ground nutmeg
  • Cut diagonally across the grain into thin slices.